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胃复方的急性毒性实验研究
胡花婷,李东芳,何侃成
0
(湖南中医药大学第一附属医院,湖南 长沙,410007;中南大学湘雅医学院附属肿瘤医院,湖南 长沙,410003;中南大学湘雅二医院,湖南 长沙,410001)
摘要:
目的:对胃复方进行急性毒性实验研究,观察其安全性。方法:将实验小鼠按体质量随机分为2组,采用最大给药量法测定小鼠口服胃复方的最大耐受量,给药组24h内2次以最大浓度、最大体积的中药胃复方给予小鼠灌胃,对照组小鼠灌服等剂量蒸馏水,观察记录2组小鼠一般情况及死亡情况,对主要脏器进行病理组织学检测。结果:给药组小鼠一般情况良好,无1例死亡。与对照组比较,体质量变化差异无统计学意义(P>0.05);主要脏器病理组织学检测未见明显异常;最大给药量为221.7g生药/kg,相当于60kg成人临床推荐剂量的127倍。结论:胃复方无明显毒性,在规定剂量下用药是安全可靠的。
关键词:  胃复方  小鼠  急性毒性实验  最大耐受量
DOI:
An experimental study of the acute toxicity of Weifu prescription
HU Huating,LI Dongfang,HE Kancheng
(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,Hunan,China;The Affiliated Tumor Hospital,Xiangya School of Medicine,Central South University,Changsha 410003,Hunan,China;The Second Xiangya Hospital of Central South University,Changsha 410001,Hunan,China)
Abstract:
Objective:To investigate the safety of Weifu prescription based on an experimental study of acute toxicity.Methods:Experimental mice were randomly divided into administration group and control group based on body weight,and the maximum administration dosage method was used to determine the maximum tolerance dose of oral Weifu prescription in mice.The mice in the administration group were given the traditional Chinese medicine Weifu prescription at the maximum concentration and volume by gavage twice within 24 hours,and those in the control group were given an equal dose of distilled water.General status and death were observed and recorded,and a histopathological examination was performed for the main visceral organs.Results:The mice in the administration group had a good general status,and no death was observed.There was no significant difference in the change in body weight between the administration group and the control group (P>0.05).The histopathological examination of the main visceral organs showed no obvious abnormalities.The maximum administration dosage was 221.7g/kg (crude drug),which was 127times the clinical recommended dose for an adult with a body weight of 60kg.Conclusion:Weifu prescription has no obvious toxicity and is safe and reliable under the prescribed dose.
Key words:  Weifu prescription  mouse  acute toxicity experiment  maximum tolerance dose

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