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补肾活血开窍方治疗急性脑梗死45 例临床观察
钟碧华,薛伟新,陈 炜
0
(贺州市平桂区人民医院,广西 贺州,542899;贺州市中医医院,广西 贺州,542899;广西中医药大学第一附属医院,广西 南宁,530023)
摘要:
目的:观察补肾活血开窍方治疗急性脑梗死的临床疗效。方法:将符合纳入标准的90 例急性脑梗死患者按随机数字表法随机分为治疗组和对照组,每组各45 例。对照组予西医常规治疗,治疗组在对照组基础上加服补肾活血开窍方治疗。2组均治疗14 d,观察2组患者治疗前后的美国国立卫生研究院卒中量表(NIHSS)、日常生活能力Barthel指数(BI)评分和血清S100钙结合蛋白β(S100β)、神经元特异性烯醇化酶(NSE)水平,记录治疗期间出现的不良反应,并评定临床疗效。结果:总有效率治疗组为93.33%(42/45),显著高于对照组的82.22%(37/45),差异有统计学意义(P<0.05);2组NIHSS、BI评分,以及S100β、NSE水平治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。治疗组出现轻微腹泻1 例,对照组出现恶心2 例,因患者症状轻微,均未做特殊处理。结论:补肾活血开窍方能显著改善急性脑梗死患者的神经缺损程度,提高日常生活能力,其机制可能与下调血清S100β、NSE水平有关。
关键词:  急性脑梗死  中西医结合疗法  补肾活血开窍方
DOI:
Clinical effect of kidney-tonifying,blood-activating,and orifice-opening prescription in treatment of acute cerebral infarction:An analysis of 45 cases
ZHONG Bihua,XUE Weixin,CHEN Wei
(The People’s Hospital of Pinggui District,Hezhou 542899,Guangxi,China;Hezhou Municipal Hospital of Traditional Chinese Medicine,Hezhou 542899,Guangxi,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,Guangxi,China)
Abstract:
Objective:To investigate the clinical effect of kidney-tonifying,blood-activating,and orifice-opening prescription in the treatment of acute cerebral infarction.Methods:A total of 90 patients who met the inclusion criteria were divided into treatment group and control group using a random number table,with 45 patients in each group.The patients in the control group were given conventional Western medicine treatment,and those in the treatment group were given kidney-tonifying,blood-activating,and orifice-opening prescription in addition to the treatment in the control group.Both groups were treated for 14 days,and then the two groups were compared in terms of the changes in National Institutes of Health Stroke Scale (NIHSS) score,activities of daily living,Barthel Index (BI) score,and serum levels of S100β and neuron-specific enolase (NSE) after treatment;adverse reactions were recorded during treatment,and clinical outcome was evaluated.Results:The treatment group had a significantly higher overall response rate than the control group[93.33% (42/45) vs 82.22% (37/45),P<0.05].Both groups had significant changes in NIHSS score,BI score,and levels of S100β and NSE after treatment,and there were significant differences in these indices between the two groups after treatment (P<0.05).One patient in the treatment group experienced mild diarrhea,and two patients in the control group experienced nausea;no special treatment was given since the symptoms were mild.Conclusion:In patients with acute cerebral infarction,kidney-tonifying,blood-activating,and orifice-opening prescription can significantly improve the degree of neurological deficit and activities of daily living,possibly by downregulating the serum levels of S100β and NSE.
Key words:  acute cerebral infarction  integrated traditional Chinese and Western medicine therapy  kidney-tonifying,blood-activating,and orifice-opening prescription

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