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基于网络药理学探讨薤白治疗肺癌的作用机制
卢 可,方 刚
0
(湖北民族大学医学部,湖北 恩施,445000;广西中医药大学,广西 南宁,530200)
摘要:
目的:运用网络药理学预测薤白治疗肺癌有效成分的作用靶点及通路。方法:通过TCMSP数据库获取薤白有效成分及作用靶点,并运用Cytoscape 3.7.1软件构建靶点间相互作用网络并进行关联分析,R×64 3.5.3软件及相应脚本筛选出薤白治疗肺癌的有效成分及作用靶点,生物信息学技术富集通路及生物过程。结果:预测得到薤白治疗肺癌有效成分11个和有效靶点30个,并推断其作用机制可能与AGE-RAGE、PI3K-Akt等信号通路有关,且JUN、MAPK1、MAPK3 等靶点基因可能起着关键性的作用。结论:基于网络药理学探讨了薤白治疗肺癌多成分-多靶点-多通路的作用特点,为进一步开展薤白治疗肺癌作用机制的研究提供了新的思路和方法。
关键词:  薤白  网络药理学  肺癌  AGE-RAGE信号通路  PI3K-Akt信号通路
DOI:
Mechanism of action of macrostem onion in treatment of lung cancer:An analysis based on network pharmacology
LU Ke,FANG Gang
(Medical Department of Hubei Minzu University,Enshi 445000,Hubei,China;Guangxi University of Chinese Medicine,Nanning 530200,Guangxi,China)
Abstract:
Objective:To investigate the targets and pathways of the effective constituents of macrostem onion in the treatment of lung cancer based on network pharmacology.Methods:TCMSP database was used to obtain the effective constituents of macrostem onion and their targets,and Cytoscape 3.7.1 software was used to establish an interaction network of the targets and perform a correlation analysis.R×64 3.5.3 software and related scripts were used to screen out the effective constituents of macrostem onion and their targets in the treatment of lung cancer,and a bioinformatics enrichment analysis was performed to identify main pathways and biological processes.Results:A total of 11 effective constituents of macrostem onion and 30 effective targets were obtained for the treatment of lung cancer,and it was predicted that the mechanism of action of macrostem onion might be associated with the AGE-RAGE and PI3K-Akt signaling pathways.The target genes,including JUN,MAPK1,and MAPK3,might play a critical role.Conclusion:The analysis based on network pharmacology shows that macrostem onion has the features of multiple constituents,multiple targets,and multiple pathways in the treatment of lung cancer,which provides new ideas and methods for further research on the mechanism of action of macrostem onion in the treatment of lung cancer.
Key words:  macrostem onion  network pharmacology  lung cancer  AGE-RAGE signaling pathway  PI3K-Akt signaling pathway

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