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热毒宁注射液治疗AECOPD的疗效及对TLR4/NF-κB炎症信号通路的影响
彭琼辉,刘 琼,刘成高
0
(湖南环境生物职业技术学院,湖南 衡阳,421001;湖南中医药大学附属衡阳医院,湖南 衡阳,421001)
摘要:
目的:观察热毒宁注射液治疗慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效及对Toll样受体4(TLR4)/核转录因子κB(NF-κB)炎症信号通路的影响,并探讨其可能作用机制。方法:将72 例AECOPD患者随机分为治疗组和对照组,每组各36 例。对照组采用西医常规治疗,治疗组在对照组治疗的基础上加用热毒宁注射液治疗。比较2组的综合疗效、中医证候积分、血清TLR4/NF-κB炎症信号通路相关炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、TLR4、NF-κB]水平。结果:总有效率治疗组为91.67%(33/36),对照组为69.44%(25/36),2组比较,差异有统计学意义(P<0.05)。治疗后2组中医证候积分、TNF-α、IL-6、IL-8、TLR4和NF-κB均降低,且治疗组降低幅度更明显,2组比较,差异均有统计学意义(P<0.05,P<0.01)。结论:热毒宁注射液联合西医常规治疗AECOPD临床疗效颇佳,能有效缓解患者炎症反应,其作用机制可能与抑制TLR4/NF-κB炎症信号通路的激活,减少其下游炎症因子的释放有关。
关键词:  慢性阻塞性肺疾病急性加重期  热毒宁注射液  TLR4/NF-κB炎症信号通路
DOI:
Clinical effect of Reduning injection in treatment of acute exacerbation of chronic obstructive pulmonary disease and its effect on the Toll-like receptor 4/nuclear factor-kappa B inflammatory signaling pathway
PENG Qionghui,LIU Qiong,LIU Chenggao
(Hunan Polytechnic of Environment and Biology,Hengyang 421001,Hunan,China;Hengyang Hospital Affiliated to Hunan University of Chinese Medicine,Hengyang 421001,Hunan,China)
Abstract:
Objective:To investigate the clinical effect of Reduning injection in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD),its effect on the Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) inflammatory signaling pathway,and its possible mechanism of action.Methods:A total of 72 patients with AECOPD were randomly divided into treatment group and control group,with 36 patients in each group.The patients in the control group were given conventional Western medicine treatment,and those in the treatment group were given Reduning injection in addition to the treatment in the control group.The two groups were compared in terms of overall response,traditional Chinese medicine (TCM) syndrome score,and serum levels of the inflammatory cytokines associated with the TLR4/NF-κB inflammatory signaling pathway including tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6),interleukin-8 (IL-8),TLR4,and NF-κB.Results:There was a significant difference in overall response rate between the treatment group and the control group [91.67% (33/36) vs 69.44% (25/36),P<0.05].After treatment,both groups had significant reductions in TCM syndrome score,TNF-α,IL-6,IL-8,TLR4,and NF-κB,and the treatment group had significantly greater reductions than the control group (P<0.05,P<0.01).Conclusion:Reduning injection combined with conventional Western medicine treatment has a marked clinical effect in the treatment of AECOPD and can effectively alleviate inflammatory response,possibly by inhibiting the activation of the TLR4/NF-κB inflammatory signaling pathway and reducing the release of its downstream inflammatory cytokines.
Key words:  acute exacerbation of chronic obstructive pulmonary disease  Reduning injection  Toll-like receptor 4/nuclear factor-kappa B inflammatory signaling pathway

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